Chemotyping the distribution of vitamin D metabolites in human serum

Chemotyping the distribution of vitamin D metabolites in human serum

Most studies examining the relationships between vitamin D and disease or health focus on the main 25-hydroxyvitamin D3 (25(OH)D3) metabolite, thus potentially overlooking contributions and dynamic effects of other vitamin D metabolites, the crucial roles of several of which have been previously demonstrated. The ideal assay would determine all relevant high and low-abundant vitamin D species s...

Serum concentrations of vitamin D metabolites in untreated tuberculosis.

A prospective study of 50 consecutive patients presenting with tuberculosis has shown that patients have on average lower serum concentrations of 25-hydroxycholecalciferol (25-OHD) than healthy matched controls. No difference was shown in serum 1,25-(OH)2D, 24,25-(OH)2D, or parathyroid hormone. Uncorrected serum calcium was lower in the patient group but identical when correction concentrations...

Value Assignment of Vitamin D Metabolites in Vitamin D Standardization Program Serum Samples.

Assay variability has been cited as an obstacle to establishing optimal vitamin D exposure. As part of the Vitamin D Standardization Program (VDSP) effort to standardize the measurement of total 25-hydroxyvitamin D [25(OH)D], the value assignment of total 25(OH)D in 50 single-donor serum samples was performed using two isotope-dilution LC with tandem MS methods. Both methods are recognized as r...

Stability of vitamin D metabolites in human blood serum and plasma.

Serum Vitamin D Concentrations in CoVID19 Patients

Background and purpose: Vitamin D deficiency is highly prevalent in Iran. Death toll due to the Coronavirus Disease 2019 (COVID-19) is high in this country. The purpose of the present investigation was to provide more information on the relationship between serum levels of vitamin D in confirmed cases of COVID-19 in north of Iran. Materials and methods: This cross-sectional descriptive study w...